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Nicotine replacement therapy for smoking cessation in pregnant women

What we are doing:

We are using existing trial data to investigate why there is an apparent lack of evidence for nicotine replacement therapy (NRT) efficacy in pregnancy thus far. We are doing this by exploring nicotine delivery of NRT in pregnancy, and user adherence to NRT during pregnancy.

We are also updating the Cochrane review using a new methodological technique called trial sequential analysis (TSA), which will enable us to see if more trials are needed.

Why we are doing it:

We are doing this to enable us to better understand how NRT is used during pregnancy, so that future interventions can be changed to become more effective in helping pregnant women stop smoking.

What the benefits will be:

Ultimately, the aim is to improve the number of women quitting smoking during pregnancy. This will mean there are greater improvements in birth outcomes, and also improved health for the mother.

Who we are working with:

We are collaborating with Ivan Berlin in France who conducted a trial of NRT in pregnancy and also Christian Gluud in Denmark, who is an expert in TSA.


Ravinder Claire,

Photo by Andres Siimon on Unsplash