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Effects of intensive interventions in individuals with type 2 diabetes mellitus and microalbuminuria

What we are doing:

In this PhD study, we aim to assess the effect of intensive interventions targeting intensive glycaemic control, blood pressure control, and lipid levels control, either singularly or in combination as a multifactorial intervention, on risk factor control and cardiovascular outcomes, compared to standard care, in individuals with type 2 diabetes and microalbuminuria, utilising evidence synthesis methodologies, and routinely collected data in the United Kingdom general practices from the Clinical Practice Research Datalink (CPRD).

Why we are doing it:

Type 2 diabetes is a progressive metabolic disorder, resulting from a combination of insulin resistance and inadequate insulin secretion. Microalbuminuria is an independent risk factor for macrovascular complications and mortality in people with type 2 diabetes. Few numbers of trials to date have been conducted in individuals with type 2 diabetes and microalbuminuria and have shown that intensive interventions result in greater improvements in metabolic control and cardiovascular risk profiles, however the collective evidence across available studies for the superiority of intensive interventions compared to standard care for reducing renal disease, cardiovascular disease, and mortality in people with type 2 diabetes and microalbuminuria is uncertain, and  needs to be evaluated.

What the benefits will be:

Evidence on the effects of intensive interventions across available studies in this population group (type 2 diabetes and microalbuminuria) is currently lacking. This study will help to inform this current gap in the literature. This study will summarize the findings from individual studies, will perform a retrospective cohort analysis of CPRD and will develop a decision model, to assess the long-term clinical and cost-effectiveness of intensive interventions in individuals  with type 2 diabetes and microalbuminuria. The results from this study will enable healthcare professionals to make a more informed decision about which intervention option will be best for individuals in this population group.

Who we are working with:

  • Diabetes Research Centre
  • University of Leicester


Muhammad Usman, PhD student, Diabetes Research Centre, University of Leicester, Leicester General Hospital,​

Photo by Gus Moretta on Unsplash